ea0021p211 | Endocrine tumours and neoplasia | SFEBES2009
Burrows Natalie
, Resch Julia
, Mejin Melissa
, Brabant Georg
, Williams Kaye
Intratumoural hypoxia is associated with aggressive and metastatic phenotypes with poor prognosis. The transcription factor HIF-1α is a key regulator of hypoxia-mediated gene expression that is documented to promote tumour growth and metastasis in a wide range of cancers. However its role in the development of thyroid carcinomas is relatively unknown. We have previously shown that HIF-1α is highly active in a range of thyroid cancer cell lines with highest activity o...